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Article

Attenuated dengue 2 viruses with deletions in capsid protein derived from an infectious full-length cDNA clone.

Virus research - 1 Jun 2007

Zhu Wuyang, Qin Chengfeng, Chen Shuping, Jiang Tao, Yu Man, Yu Xuedong, Qin Ede

Abstract excerpt

A full-length cDNA clone (pD212) of dengue virus type 2 isolated in China (DEN2-43) was constructed. Based on this, we constructed several mutants with deletions in capsid protein C using fusion PCR. These deletions removed part or almost all of the internal stretch of hydrophobic amino acid residues that is probably involved in virion assembly. We thus obtained viable mutant viruses. The propagation capacity of...

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Identifiers

PMID: 17412442
DOI: 10.1016/j.virusres.2007.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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