Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.

Gene - 1 Jan 2013

Al Rayyan Numan, Wankhade Umesh D, Bush Korie, Good Deborah J

Abstract excerpt

Nescient helix-loop-helix-2 (NHLH2) is a basic helix-loop-helix transcription factor, which has been implicated, using mouse knockouts, in adult body weight regulation and fertility. A scan of the known single nucleotide polymorphisms (SNPs) in the NHLH2 gene revealed one in the 3' untranslated region (3'UTR), which lies within an AUUUA RNA stability motif. A second SNP is nonsynonymous within the coding region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Obesity

Share to Open Reading Frames

Share to Protein Conformation

Share to Protein Interaction Domains and Motifs

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 23026212
DOI: 10.1016/j.gene.2012.09.068
PMCID: PMC3505891

Genes

NHLH2
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Two single nucleotide polymorphisms in the human nescient helix-loop-helix 2 (NHLH2) gene reduce mRNA stability and DNA binding.PMID 23026212Read ↗

Nhlh2Semantic proximity Read ↗

Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans.Semantic proximity Read ↗

Inactivating NHLH2 Variants Cause Idiopathic Hypogonadotropic Hypogonadism and Obesity in HumansSemantic proximity Read ↗

Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation.Semantic proximity Read ↗

A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate.Semantic proximity Read ↗

Association of NEDD4L ubiquitin ligase with essential hypertension.Semantic proximity Read ↗

Subcellular partitioning of <i>Nhlh2</i> mRNA reveals how <i>SNORD116</i> loss contributes to Prader-Willi SyndromeSemantic proximity Read ↗

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.Semantic proximity Read ↗

Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice.Semantic proximity Read ↗

Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA.Semantic proximity Read ↗

A human Id-like helix-loop-helix protein expressed during early development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.