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Article

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.

The EMBO journal - 30 May 2012

Ishii Ryohei, Isogaya Kazunobu, Seto Azusa, Koinuma Daizo, Watanabe Yuji, Arisaka Fumio, Yaguchi So-ichi, Ikushima Hiroaki, Dohmae Naoshi, Miyazono Kohei, Miyazawa Keiji, Ishitani Ryuichiro, Nureki Osamu

Abstract excerpt

Helix-loop-helix (HLH) family transcription factors regulate numerous developmental and homeostatic processes. Dominant-negative HLH (dnHLH) proteins lack DNA-binding ability and capture basic HLH (bHLH) transcription factors to inhibit cellular differentiation and enhance cell proliferation and...

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Source

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Identifiers

PMID: 22453338
DOI: 10.1038/emboj.2012.77
PMCID: PMC3365425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22453338-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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