Association between a gain-of-function variant of PTPN22 and rejection in liver transplantation.

doi:10.1097/TP.0000000000000313

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Article

Association between a gain-of-function variant of PTPN22 and rejection in liver transplantation.

Transplantation - 1 Feb 2015

Dullin Raphael, Koch Martina, Sterneck Martina, Nashan Björn, Thude Hansjörg

Abstract excerpt

BACKGROUND: The protein tyrosine phosphatase nonreceptor 22 gene (PTPN22) encodes a strong T-cell regulator called lymphoid protein tyrosine phosphatase. Previously, PTPN22 was described as a susceptibility gene for autoimmunity because it contains single nucleotide polymorphisms (SNPs) associated with several autoimmune diseases. One SNP (rs2476601; 1858G>A) has emerged as a particularly potent risk factor for...

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PMID: 25073032
DOI: 10.1097/TP.0000000000000313

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PTPN22

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