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Article

Intratumoral heterogeneity of KRAS mutation is rare in non-small-cell lung cancer.

Experimental and molecular pathology - 1 Feb 2013

Alsdorf Winfried H, Clauditz Till S, Hoenig Tobias, Quaas Alexander, Sirma Hüseyin, Koenig Alexandra M, Izbicki Jakob, Sauter Guido, Marx Andreas H, Grob Tobias J

Abstract excerpt

BACKGROUND: Several lines of evidence indicate that mutational activation of KRAS is an early event in the carcinogenesis of non-small cell lung cancer (NSCLC). Nonetheless, previous studies report high frequencies of divergent KRAS mutational status between primary NSCLC and corresponding metastases. This suggests heterogeneity of the primary tumor in respect to its KRAS status. We therefore aimed to examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23022742
DOI: 10.1016/j.yexmp.2012.09.016

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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