Article
Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2011
Wagner Patrick L, Stiedl Ann-Cathrin, Wilbertz Theresia, Petersen Karen, Scheble Veit, Menon Roopika, Reischl Markus, Mikut Ralf, Rubin Mark A, Fend Falko, Moch Holger, Soltermann Alex, Weder Walter, Altorki Nasser K, Perner Sven
Abstract excerpt
BACKGROUND: Characterization of the non-small cell lung cancer (NSCLC) genome has suggested that KRAS amplification is one of the commonest molecular abnormalities in NSCLC. However, the prevalence and clinicopathologic significance of KRAS amplification, and its relationship with KRAS activating mutations have not been well-defined. The purpose of this study was to establish the prevalence of KRAS amplification...
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