Article
IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years.
The Journal of allergy and clinical immunology - 1 Mar 2013
Raedler Diana, Illi Sabina, Pinto Leonardo Araujo, von Mutius Erika, Illig Thomas, Kabesch Michael, Schaub Bianca
Abstract excerpt
BACKGROUND: IL10 encodes for IL-10, an important anti-inflammatory cytokine with pleiotropic effects. It is crucial for development of immune tolerance, downregulates expression of TH1 cytokines, and is relevant for T-cell regulation. Several IL10 single nucleotide polymorphisms (SNPs) were associated with inflammatory diseases, such as atopic diseases, which might have their onset during early immune maturation....
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