IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort.

doi:10.1111/pai.12597

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Article

IL-33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Nov 2016

Schröder Paul C, Casaca Vera I, Illi Sabina, Schieck Maximilian, Michel Sven, Böck Andreas, Roduit Caroline, Frei Remo, Lluis Anna, Genuneit Jon, Pfefferle Petra, Roponen Marjut, Weber Juliane, Braun-Fahrländer Charlotte, Riedler Josef, Lauener Roger, Vuitton Dominique Angèle, Dalphin Jean-Charles, Pekkanen Juha, von Mutius Erika, Kabesch Michael, Schaub Bianca

Abstract excerpt

BACKGROUND: IL-33 polymorphisms influence the susceptibility to asthma. IL-33 indirectly induces Th2-immune responses via dendritic cell activation, being important for development of atopic diseases. Furthermore, IL-33 upregulates regulatory T cells (Tregs), which are critical for healthy immune homeostasis. This study investigates associations between IL-33 polymorphisms during the development of childhood...

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PMID: 27171815
DOI: 10.1111/pai.12597

Genes

SOCS3
FOXP3
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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