Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

3D Homology Model of Sigma1 Receptor.

Handbook of experimental pharmacology - 1 Jan 2017

Laurini Erik, Marson Domenico, Fermeglia Maurizio, Pricl Sabrina

Abstract excerpt

This chapter presents the three-dimensional (3D) model of the Sigma1 receptor protein as obtained from homology modeling techniques. We show the applicability of this structure to docking-based virtual screening and discuss combined in silico/in vitro mutagenesis studies performed to validate the structural features of the Sigma1 receptor model and to qualify/quantify the prominent role of specific amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ligands
Share to Models, Molecular
Share to Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Binding

Share to Protein Conformation

Share to Signal Transduction

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 28667476
DOI: 10.1007/164_2017_35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

3D Homology Model of Sigma1 Receptor.PMID 28667476Read ↗

5D-QSAR for spirocyclic sigma1 receptor ligands by Quasar receptor surface modeling.Semantic proximity Read ↗

Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands.Semantic proximity Read ↗

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR modelsSemantic proximity Read ↗

Virtual screening identifies novel high-affinity σ <sub>1</sub> receptor ligandsSemantic proximity Read ↗

Three-dimensional models of estrogen receptor ligand binding domain complexes, based on related crystal structures and mutational and structure-activity relationship data.Semantic proximity Read ↗

Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis.Semantic proximity Read ↗

The human VPAC1 receptor: three-dimensional model and mutagenesis of the N-terminal domain.Semantic proximity Read ↗

Sequence variants of the ligand-binding domain of the glucocorticoid receptor gene and their functional consequences on the three-dimensional protein structure.Semantic proximity Read ↗

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic StabilitySemantic proximity Read ↗

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain.Semantic proximity Read ↗

NRSAS: Nuclear Receptor Structure Analysis Servers.Semantic proximity Read ↗

3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.