Article

Virtual screening identifies novel high-affinity σ <sub>1</sub> receptor ligands

2019-07-11

Abstract excerpt

The σ 1 receptor is a transmembrane protein implicated in several pathophysiological conditions, including neurodegenerative disease 1 , drug addiction 2 , cancer 3 , and pain 4 . However, there are no high-throughput functional assays for σ 1 receptor drug discovery. Here, we assessed high-throughput structure-based computational docking for discovery of novel ligands of the σ 1 receptor. We screened a lib...

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Literature Corpus work: 894f1ad9-cf0e-54da-bb3b-08d57c06e66b
DOI: 10.1101/699793

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