Article
AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.
Molecular cell - 7 Apr 2006
Vaucheret Hervé, Mallory Allison C, Bartel David P
Abstract excerpt
Arabidopsis ARGONAUTE1 (AGO1) encodes the RNA slicer enzyme of the microRNA (miRNA) pathway and is regulated by miR168-programmed, AGO1-catalyzed mRNA cleavage. Here, we describe two additional regulatory processes required for AGO1 homeostasis: transcriptional coregulation of MIR168 and AGO1 genes, and posttranscriptional stabilization of miR168 by AGO1. Disrupting any of these regulatory processes by using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
