Article
The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA.
Nucleic acids research - 1 Nov 2011
Martínez de Alba Angel Emilio, Jauvion Vincent, Mallory Allison C, Bouteiller Nathalie, Vaucheret Hervé
Abstract excerpt
In plants, most microRNAs (miRNAs) and several endogenous small interfering RNAs (siRNAs) bind to ARGONAUTE1 (AGO1) to regulate the expression of endogenous genes through post-transcriptional gene silencing (PTGS). AGO1 also participates in a siRNA-mediated PTGS defense response that thwarts exogenous RNA deriving from viruses and transgenes. Here, we reveal that plants supporting transgene PTGS exhibit increased...
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