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Article

Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.

Human genetics - 1 Jul 2013

Zuo Lingjun, Wang Kesheng, Zhang Xiang-Yang, Pan Xinghua, Wang Guilin, Tan Yunlong, Zhong Chunlong, Krystal John H, State Matthew, Zhang Heping, Luo Xingguang

Abstract excerpt

Humans express at least seven alcohol dehydrogenase (ADH) isoforms that are encoded by ADH gene cluster (ADH7-ADH1C-ADH1B-ADH1A-ADH6-ADH4-ADH5) at chromosome 4. ADHs are key catabolic enzymes for retinol and ethanol. The functional ADH variants (mostly rare) have been implicated in alcoholism risk. In addition to catalyzing the oxidation of retinol and ethanol, ADHs may be involved in the metabolic pathways of...

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Identifiers

PMID: 23468174
DOI: 10.1007/s00439-013-1277-4
PMCID: PMC3683370

Genes

ADH4
ADH5
ADH6
ADH7
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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