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Article

Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.

Biological psychiatry - 1 Jul 2025

Wang Lu, Kranzler Henry R, Gelernter Joel, Zhou Hang

Abstract excerpt

BACKGROUND: Alcohol use disorder (AUD) is a leading cause of death and disability worldwide. There has been substantial progress in identifying genetic variants that underlie AUD. However, whole-exome sequencing studies of AUD have been hampered by the lack of available samples. METHODS: We analyzed whole-exome sequencing data of 4530 samples from the Yale-Penn cohort and 469,835 samples from the UK Biobank,...

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Identifiers

PMID: 39892688
DOI: 10.1016/j.biopsych.2025.01.020
PMCID: PMC12167164

Genes

ADH1B
ADH1C
CNST

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