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Article

Partial oligomerization of pyolysin induced by a disulfide-tethered mutant.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Dec 2012

Pokrajac Lisa, Baik Clara, Harris J Robin, Sarraf Naghmeh S, Palmer Michael

Abstract excerpt

The bacterial toxin pyolysin (PLO) belongs to the family of cholesterol-dependent cytolysins (CDCs), which form large, ring-shaped oligomeric pores in cholesterol-containing membranes. Monomeric CDC molecules have a structure of four domains, with domains 2 and 3 packed against each other. After binding to target membranes containing cholesterol, toxin monomers oligomerize into pre-pore complexes. Trans-membrane...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23016571
DOI: 10.1139/o2012-029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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