Article
Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerization.
The EMBO journal - 16 Mar 1998
Palmer M, Harris R, Freytag C, Kehoe M, Tranum-Jensen J, Bhakdi S
Abstract excerpt
Streptolysin O (SLO) is a bacterial exotoxin that binds to cell membranes containing cholesterol and then oligomerizes to form large pores. Along with rings, arc-shaped oligomers form on membranes. It has been suggested that each arc represents an incompletely assembled oligomer and constitutes a...
Topics
- Animals
- Bacterial Proteins
- Cell Membrane Permeability
- Complement Hemolytic Activity Assay
- Cysteine
- Erythrocyte Membrane
- Membrane Lipids
- Mutation
- Naphthalenesulfonates
- Protein Conformation
- Rabbits
- Streptolysins