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Article

Engineered covalent leucotoxin heterodimers form functional pores: insights into S-F interactions.

The Biochemical journal - 1 Jun 2006

Joubert Olivier, Viero Gabriella, Keller Daniel, Martinez Eric, Colin Didier A, Monteil Henri, Mourey Lionel, Dalla Serra Mauro, Prévost Gilles

Abstract excerpt

The staphylococcal alpha-toxin and bipartite leucotoxins belong to a single family of pore-forming toxins that are rich in beta-strands, although the stoichiometry and electrophysiological characteristics of their pores are different. The different known structures show a common beta-sandwich domain that plays a key role in subunit-subunit interactions, which could be targeted to inhibit oligomerization of these...

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Identifiers

PMID: 16494579
DOI: 10.1042/BJ20051878
PMCID: PMC1462717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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