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Article

Impacts of dietary selenium deficiency on metabolic phenotypes of diet-restricted GPX1-overexpressing mice.

Antioxidants & redox signaling - 1 Feb 2011

Pepper Matthew P, Vatamaniuk Marko Z, Yan Xi, Roneker Carol A, Lei Xin Gen

Abstract excerpt

We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficiency eliminated these two primary effects of GPX1 overproduction. Forty-seven male OE and...

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Source

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Identifiers

PMID: 20578960
DOI: 10.1089/ars.2010.3295
PMCID: PMC3026648

Genes

GPX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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