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Article

Functional matrix metalloproteinase (MMP)-9 genetic variants modify the effects of hemodialysis on circulating MMP-9 levels.

Clinica chimica acta; international journal of clinical chemistry - 24 Dec 2012

Marson Bernardo P, Lacchini Riccardo, Belo Vanessa, Mattos Silvia G, da Costa Bartira P, Poli-de-Figueiredo Carlos E, Tanus-Santos Jose E

Abstract excerpt

BACKGROUND: Altered levels of matrix metalloproteinases (MMPs) and their inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), are involved in cardiovascular alterations associated with end stage kidney disease (ESKD). Genetic polymorphisms in MMP-9 gene affect MMP-9 levels. We examined how MMP-9 polymorphisms and haplotypes affect the changes in plasma MMP-9 and TIMP-1 levels found in patients with...

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Identifiers

PMID: 23010359
DOI: 10.1016/j.cca.2012.08.014

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