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Article

Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.

The pharmacogenomics journal - 1 Dec 2012

Palei A C T, Sandrim V C, Amaral L M, Machado J S R, Cavalli R C, Lacchini R, Duarte G, Tanus-Santos J E

Abstract excerpt

Abnormal matrix metalloproteinase (MMP)-9 levels may have a role in hypertensive disorders of pregnancy. We examined whether MMP-9 genetic polymorphisms (g.-1562C >T and g.-90(CA)13-25) modify plasma MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 levels and the responses to antihypertensive therapy in 214 patients with preeclampsia (PE), 185 patients with gestational hypertension (GH) and a control...

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Identifiers

PMID: 21769110
DOI: 10.1038/tpj.2011.31

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Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.PMID 21769110Read ↗

Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension.Semantic proximity Read ↗

Tissue inhibitor of matrix metalloproteinase-1 polymorphism, plasma TIMP-1 levels, and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.Semantic proximity Read ↗

Effects of matrix metalloproteinase (MMP)-2 polymorphisms on responsiveness to antihypertensive therapy of women with hypertensive disorders of pregnancy.Semantic proximity Read ↗

Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy.Semantic proximity Read ↗

Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients.Semantic proximity Read ↗

Genetic variants in matrix metalloproteinase-9 gene modify metalloproteinase-9 levels in black subjects.Semantic proximity Read ↗

Non-association of MMP-9 -1562C/T polymorphism with preeclampsia risk: evidence from a meta-analysis.Semantic proximity Read ↗

Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children.Semantic proximity Read ↗

Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia.Semantic proximity Read ↗

Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy.Semantic proximity Read ↗

Matrix metalloproteinase-2 -735C/T polymorphism is associated with resistant hypertension in a specialized outpatient clinic in Brazil.Semantic proximity Read ↗

Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects.Semantic proximity Read ↗

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