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Article

Matrix metalloproteinase (MMP)-2 genetic variants modify the circulating MMP-2 levels in end-stage kidney disease.

American journal of nephrology - 1 Jan 2012

Marson Bernardo P, Lacchini Riccardo, Belo Vanessa, Dickel Samantha, da Costa Bartira P, Poli de Figueiredo Carlos E, Tanus-Santos Jose E

Abstract excerpt

BACKGROUND: Matrix metalloproteinases (MMPs) play important roles in the pathophysiology of renal diseases, and imbalanced MMP-2 and its endogenous inhibitor (the tissue inhibitor of metalloproteinases-2; TIMP-2) are implicated in the vascular alterations of end-stage kidney disease (ESKD) patients. We have examined whether MMP-2 gene polymorphisms and haplotypes modify MMP-2 and TIMP-2 levels in ESKD patients as...

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PMID: 22302011
DOI: 10.1159/000336108

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