Article
β-catenin and K-ras mutations and RASSF1A promoter methylation in Taiwanese colorectal cancer patients.
Genetic testing and molecular biomarkers - 1 Nov 2012
Chen Shee-Ping, Wu Chang-Chieh, Huang Sung-Ying, Kang Jung-Cheng, Chiu Sheng-Chun, Yang Kuo-Liang, Pang Cheng-Yoong
Abstract excerpt
AIMS: The purpose of this study was to investigate the associations of β-catenin mutations, K-ras mutations, methylations of the RASSF1A promoter, and the survival of Taiwanese colorectal cancer (CRC) subjects who received 5-fluorouracil (5-FU) adjuvant chemotherapy. RESULTS: The complete coding region of the K-ras gene and exon 3 and exon 4 of the β-catenin gene isolated from tumor tissues and adjacent normal...
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