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Article

Identification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA display.

18 Jul 1995

Abstract excerpt

Elucidating the relevant genomic changes mediating development and evolution of prostate cancer is paramount for effective diagnosis and therapy. A putative dominant-acting nude mouse prostatic carcinoma tumor-inducing gene, PTI-1, has been cloned that is expressed in patient-derived human prostatic carcinomas but not in benign prostatic hypertrophy or normal prostate tissue. PTI-1 was detected by cotransfecting...

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PMID: 7542776
DOI: 10.1073/pnas.92.15.6778

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