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Article

Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype.

Oncogene - 1 Nov 1992

Albino A P, Sozzi G, Nanus D M, Jhanwar S C, Houghton A N

Abstract excerpt

Human melanoma provides a model to study malignant transformation and tumor progression. Expression of ras oncogenes in cultured normal human diploid melanocytes has induced a subset of phenotypic traits that are characteristic of malignant melanoma cells, including altered morphology, anchorage independence, induction of class II MHC antigens, up-regulation of the ganglioside GD3, and chromosomal abnormalities....

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PMID: 1437153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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