Article
Malignant transformation of human melanocytes: induction of a complete melanoma phenotype and genotype.
Oncogene - 1 Nov 1992
Albino A P, Sozzi G, Nanus D M, Jhanwar S C, Houghton A N
Abstract excerpt
Human melanoma provides a model to study malignant transformation and tumor progression. Expression of ras oncogenes in cultured normal human diploid melanocytes has induced a subset of phenotypic traits that are characteristic of malignant melanoma cells, including altered morphology, anchorage independence, induction of class II MHC antigens, up-regulation of the ganglioside GD3, and chromosomal abnormalities....
Topics
- 3T3 Cells
- Animals
- Antigens, Surface
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 6
- Genes, ras
- Genotype
- HLA-DR Antigens
- Humans