Article
N-ras oncogene expression changes the growth characteristics of human melanoma in two independent SCID-hu mouse models.
International journal of cancer - 17 Sept 1996
Jansen B, Inoue S A, Wadl H, Eichler H G, Wolff K, Van Elsas A, Schrier P I, Pehamberger H
Abstract excerpt
Fifteen percent of all human melanomas carry mutations in ras genes, the majority of which are located in codon 61 of the N-ras gene. However, the biological significance of these mutations is as yet unknown. In this study, we investigated the influence of N-ras oncogene products mutated in codon 61 on the growth characteristics of human melanoma in vivo by establishing 2 SCID-hu mouse xenotransplantation models....
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