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Article

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.

BMC cancer - 3 Feb 2014

Liu Xianpeng, Gu Xin, Sun Limin, Flowers Ashley B, Rademaker Alfred W, Zhou Yiran, Kiyokawa Hiroaki

Abstract excerpt

BACKGROUND: The HECT family ubiquitin ligase Smurf2 regulates cell polarity, migration, division, differentiation and death, by targeting diverse substrates that are critical for receptor signaling, cytoskeleton, chromatin remodeling and transcription. Recent studies suggest that Smurf2 functions...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Ductal, Breast
Share to Carcinoma, Intraductal, Noninfiltrating
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Retinoblastoma Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 24485087
DOI: 10.1186/1471-2407-14-57
PMCID: PMC3918234

Genes

SMURF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24485087-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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