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Article

Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.

The Journal of biological chemistry - 9 Nov 2012

Hukkelhoven Ellen, Liu Yuhui, Yeh Nancy, Ciznadija Daniel, Blain Stacy W, Koff Andrew

Abstract excerpt

Phosphorylation of Tyr-88/Tyr-89 in the 3(10) helix of p27 reduces its cyclin-dependent kinase (CDK) inhibitory activity. This modification does not affect the interaction of p27 with cyclin-CDK complexes but does interfere with van der Waals and hydrogen bond contacts between p27 and amino acids in the catalytic cleft of the CDK. Thus, it had been suggested that phosphorylation of this site could switch the...

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Identifiers

PMID: 23007395
DOI: 10.1074/jbc.M112.366542
PMCID: PMC3493897

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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