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Article

Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation.

The Biochemical journal - 15 Jan 2013

Huang Wan, Luo Wen-Juan, Zhu Ping, Tang Juan, Yu Xiao-Ling, Cui Hong-Yong, Wang Bin, Zhang Yang, Jiang Jian-Li, Chen Zhi-Nan

Abstract excerpt

Degradation of the basement membrane by MMPs (matrix metalloproteinases) is one of the most critical steps in tumour progression. CD147 is a tumour-associated antigen that plays a key regulatory role for MMP activities. In the present study, mass spectrum analysis demonstrated that the purified native CD147 from human lung cancer tissue was N-glycosylated and contained a series of high-mannose and complex-type...

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PMID: 23005037
DOI: 10.1042/BJ20120343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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