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Article

Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway.

Biochemical and biophysical research communications - 16 Mar 2012

Cui Hong-Yong, Guo Tao, Wang Shi-Jie, Zhao Pu, Dong Zhi-Shou, Zhang Yang, Jiang Jian-Li, Chen Zhi-Nan, Yu Xiao-Ling

Abstract excerpt

HAb18G/CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily (IgSF) and is reported to be correlated with invasion and metastasis of many cancers. The crystal structure of HAb18G/CD147 ectodomain has shown that it can form homodimers in crystal. However, the functional significance of HAb18G/CD147 dimerization remains unclear. In the present study, guided by the crystal structure, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22366034
DOI: 10.1016/j.bbrc.2012.02.049

Genes

MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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