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Article

N-glycosylated GPNMB ligand independently activates mutated EGFR signaling and promotes metastasis in NSCLC.

Cancer science - 1 May 2021

Han Chia-Li, Chen Xuan-Ren, Lan Albert, Hsu Yuan-Ling, Wu Pei-Shan, Hung Pei-Fang, Hung Chung-Lieh, Pan Szu-Hua

Abstract excerpt

Lung cancer is the leading cause of cancer-related death worldwide. As well as the identified role of epidermal growth factor receptor (EGFR), its association with driver mutations has improved the therapeutics for patients with lung cancer harboring EGFR mutations. These patients usually display shorter overall survival and a higher tendency to develop distant metastasis compared with those carrying the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33706413
DOI: 10.1111/cas.14872
PMCID: PMC8088973

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