Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases

30 Mar 2021

Abstract excerpt

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits mitochondrial apoptosis under treatment with radiation and chemotherapy. It also induces excessive apoptosis in cardiovascular and/or neurodegenerative diseases. PUMA has been found to play a critical role in ovarian apoptosis. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33783663
DOI: 10.1007/s10495-021-01667-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseasesPMID 33783663Read ↗

Puma, a critical mediator of cell death — one decade on from its discoverySemantic proximity Read ↗

The p53 Upregulated Modulator of Apoptosis (PUMA) Chemosensitizes Intrinsically Resistant Ovarian Cancer Cells to Cisplatin by Lowering the Threshold Set by Bcl-xL and Mcl-1Semantic proximity Read ↗

p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseasesSemantic proximity Read ↗

The role of p53 in apoptosis.Semantic proximity Read ↗

Targeting the p53 Pathway of ApoptosisSemantic proximity Read ↗

[Molecular bases of the programmed cell death process: implications of tumor suppressor protein p53 and other proteins in the control of cell cycle. Mechanisms of apoptotic action. Review].Semantic proximity Read ↗

CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER StressSemantic proximity Read ↗

BCL-2 family isoforms in apoptosis and cancerSemantic proximity Read ↗

The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells.Semantic proximity Read ↗

The ARTS of p53-dependent mitochondrial apoptosisSemantic proximity Read ↗

Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovarySemantic proximity Read ↗

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.