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Article

The role of ROS and subsequent DNA-damage response in PUMA-induced apoptosis of ovarian cancer cells.

Oncotarget - 4 Apr 2017

Yang Jun, Zhao Xinyu, Tang Mei, Li Lei, Lei Yi, Cheng Ping, Guo Wenhao, Zheng Yu, Wang Wei, Luo Na, Peng Yong, Tong Aiping, Wei Yuquan, Nie Chunlai, Yuan Zhu

Abstract excerpt

PUMA is a member of the "BH3-only" branch of the BCL-2 family. Our previous study suggests a therapeutic potential of PUMA in treating ovarian cancer, however, the action mechanism of PUMA remains elusive. In this work, we found that in PUMA adenovirus-infected A2780s ovarian cancer cells, exogenous PUMA was partially accumulated in the cytosol and mainly located to the mitochondria. We further showed that PUMA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28423586
DOI: 10.18632/oncotarget.15626
PMCID: PMC5410321

Genes

ATM
ATR
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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