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Article

Lithium enhances CRTC oligomer formation and the interaction between the CREB coactivators CRTC and CBP--implications for CREB-dependent gene transcription.

Cellular signalling - 1 Jan 2013

Heinrich Annette, von der Heyde Anne Sophie, Böer Ulrike, Phu Do Thanh, Tzvetkov Mladen, Oetjen Elke

Abstract excerpt

Lithium salts are important drugs to treat bipolar disorder. Previous work showed that lithium by enforcing the interaction between the transcription factor CREB and its coactivator CRTC1 enhanced cAMP-stimulated CREB-dependent gene transcription. Both CREB and CRTC have been implicated in neuron...

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Source

Identifiers

PMID: 23000340
DOI: 10.1016/j.cellsig.2012.09.016

Genes

CRTC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23000340-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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