Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content.

Biological psychiatry - 15 Dec 2007

Mao Zhengquan, Liu Liqin, Zhang Rusheng, Li Xiaohua

Abstract excerpt

BACKGROUND: Forkhead box, class O (FoxO) transcription factors play important roles in cell fate, differentiation, survival, and stress regulation. A subtype of mammalian FoxO transcription factors, FoxO3a, is widely distributed in the brain, and its activity is regulated by neurotrophins, such as brain-derived neurotrophic factor (BDNF), resulting in transcriptional inactivation of FoxO3a. Searching for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Chromatin Immunoprecipitation
Share to Forkhead Box Protein O3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Intracellular Fluid

Share to Lithium

Share to Neuroblastoma

Share to Transfection

Source

Identifiers

PMID: 17574214
DOI: 10.1016/j.biopsych.2007.01.006

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content.PMID 17574214Read ↗

Molecular Signatures of Lithium Treatment: Current KnowledgeSemantic proximity Read ↗

Lithium reduces Gsk3b mRNA levels: implications for Alzheimer DiseaseSemantic proximity Read ↗

Exploring lithium’s transcriptional mechanisms of action in bipolar disorder: a multi-step studySemantic proximity Read ↗

FOXO protects against age‐progressive axonal degenerationSemantic proximity Read ↗

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cellsSemantic proximity Read ↗

Differential contributions of circadian clock genes to cell survival in bipolar disorder patient derived neuronal progenitor cells distinguishes lithium responders and non-respondersSemantic proximity Read ↗

Lithium-related genetics of bipolar disorderSemantic proximity Read ↗

FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.Semantic proximity Read ↗

Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depressionSemantic proximity Read ↗

Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatmentSemantic proximity Read ↗

Altered mRNA expression levels of autophagy- and apoptosis-related genes in the FOXO pathway in schizophrenia patients treated with olanzapineSemantic proximity Read ↗

Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor geneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.