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Article

Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge.

The American journal of psychiatry - 1 Oct 1999

Ikonomov O C, Manji H K

Abstract excerpt

OBJECTIVE: The authors critically examine the evidence supporting the hypothesis that lithium's therapeutic effects in bipolar affective disorder are mediated by alterations in the expression of specific genes in critical neuronal circuits. METHOD: Using the heuristic "initiation and adaptation paradigm," the authors appraise the biological effects and underlying molecular and cellular mechanisms of lithium's...

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Identifiers

PMID: 10518159
DOI: 10.1176/ajp.156.10.1506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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