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Article

Alterations in phosphorylated cAMP response element-binding protein (pCREB) signaling: an endophenotype of lithium-responsive bipolar disorder?

Bipolar disorders - 1 Dec 2013

Alda Martin, Shao Li, Wang Jun-Feng, Lopez de Lara Catalina, Jaitovich-Groisman Iris, Lebel Veronique, Sun Xiujun, Duffy Anne, Grof Paul, Rouleau Guy A, Turecki Gustavo, Young L Trevor

Abstract excerpt

OBJECTIVES: Abnormalities of signal transduction are considered among the susceptibility factors for bipolar disorder (BD). These include changes in G-protein-mediated signaling and subsequent modification of gene expression via transcription factors such as cAMP response element-binding protein (CREB). METHODS: We investigated levels of CREB in lymphoblasts from patients with BD, all responders to lithium...

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PMID: 24238631
DOI: 10.1111/bdi.12131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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