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Article

Targeting CREB for Cancer Therapy: Friend or Foe

1 May 2010

Abstract excerpt

The cyclic-AMP response element-binding protein (CREB) is a nuclear transcription factor activated by phosphorylation at Ser133 by multiple serine/threonine (Ser/Thr) kinases. Upon phosphorylation, CREB binds the transcriptional co-activator, CBP (CREB-binding protein), to initiate CREB-dependent gene transcription. CREB is a critical regulator of cell differentiation, proliferation and survival in the nervous...

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PMID: 20370681
DOI: 10.2174/156800910791208535

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