Article
Arabidopsis AtRRP44A is the functional homolog of Rrp44/Dis3, an exosome component, is essential for viability and is required for RNA processing and degradation.
PloS one - 1 Jan 2013
Kumakura Naoyoshi, Otsuki Hiroka, Tsuzuki Masayuki, Takeda Atsushi, Watanabe Yuichiro
Abstract excerpt
The RNA exosome is a multi-subunit complex that is responsible for 3' to 5' degradation and processing of cellular RNA. Rrp44/Dis3 is the catalytic center of the exosome in yeast and humans. However, the role of Rrp44/Dis3 homologs in plants is still unidentified. Here, we show that Arabidopsis AtRRP44A is the functional homolog of Rrp44/Dis3, is essential for plant viability and is required for RNA processing...
Topics
- Arabidopsis
- Arabidopsis Proteins
- Exosome Multienzyme Ribonuclease Complex
- Humans
- Mutation
- RNA Processing, Post-Transcriptional
- RNA Stability
- RNA, Messenger
- RNA, Plant
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology