Article
Circulating PIK3CA mutation detection at diagnosis in non-metastatic inflammatory breast cancer patients.
Scientific reports - 15 Dec 2021
Allouchery Violette, Perdrix Anne, Calbrix Céline, Berghian Anca, Lequesne Justine, Fontanilles Maxime, Leheurteur Marianne, Etancelin Pascaline, Sarafan-Vasseur Nasrin, Di Fiore Frédéric, Clatot Florian
Abstract excerpt
Inflammatory breast cancer (IBC) is an aggressive BC subtype with poor outcomes. A targetable somatic PIK3CA mutation is reported in 30% of IBC, allowing for treatment by PI3Kα-specific inhibitors, such as alpelisib. The aim of this study was to evaluate the detection rate of circulating PIK3CA mutation in locally-advanced IBC (LAIBC) patients harbouring a PIK3CA mutation on initial biopsy. This monocentric...
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