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IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma

18 Apr 2018

Abstract excerpt

Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of invasive lobular breast cancer that is associated with poor clinical outcomes. Limited molecular data are available to explain the mechanistic basis for PILC behavior. To address this issue, targeted sequencing was performed to identify molecular alterations that define PILC. This sequencing analysis identified genes that distinguish PILC...

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PMID: 29669935
DOI: 10.1172/jci.insight.97398

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