Article
Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan.
Hematological oncology - 1 Sept 2017
Sasaki Yuya, Guo Ying, Arakawa Fumiko, Miyoshi Hiroaki, Yoshida Noriaki, Koga Yuhki, Nakashima Kazutaka, Kurita Daisuke, Niino Daisuke, Seto Masao, Ohshima Koichi
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal proliferation of CD1a- and CD207 (langerin)-positive dendritic cells. Mutated BRAF (p.V600E) is observed in histiocyte-related diseases and dendritic cell-related diseases, including LCH. BRAFV600E is observed in some L...
Topics
- Adolescent
- Adult
- Aged
- Amino Acid Substitution
- Biomarkers
- Biopsy
- Child
- Child, Preschool
- Codon
- Combined Modality Therapy
- DNA Mutational Analysis
- Exons
- Female
- Histiocytosis, Langerhans-Cell
- Humans
- Immunohistochemistry
- Infant
- Infant, Newborn