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Article

Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan.

Hematological oncology - 1 Sept 2017

Sasaki Yuya, Guo Ying, Arakawa Fumiko, Miyoshi Hiroaki, Yoshida Noriaki, Koga Yuhki, Nakashima Kazutaka, Kurita Daisuke, Niino Daisuke, Seto Masao, Ohshima Koichi

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal proliferation of CD1a- and CD207 (langerin)-positive dendritic cells. Mutated BRAF (p.V600E) is observed in histiocyte-related diseases and dendritic cell-related diseases, including LCH. BRAFV600E is observed in some LCH cases and is thought to be involved in maintaining MAPK activation. We retrospectively analyzed BRAFV600E in 19...

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Identifiers

PMID: 27041734
DOI: 10.1002/hon.2293

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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