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Article

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2011

Morris Luc G T, Taylor Barry S, Bivona Trever G, Gong Yongxing, Eng Stephanie, Brennan Cameron W, Kaufman Andrew, Kastenhuber Edward R, Banuchi Victoria E, Singh Bhuvanesh, Heguy Adriana, Viale Agnes, Mellinghoff Ingo K, Huse Jason, Ganly Ian, Chan Timothy A

Abstract excerpt

Activation of the PI3K and epidermal growth factor receptor (EGFR) pathway is able to drive oncogenesis in multiple human cancers, including head and neck squamous cell carcinoma. Targeted agents such as cetuximab and erlotinib are currently used in patients with head and neck squamous cell carci...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 19

Share to Comparative Genomic Hybridization

Share to Gene Knockdown Techniques

Share to Head and Neck Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Source

Open in PubMed Open full text

Identifiers

PMID: 22065749
DOI: 10.1073/pnas.1111963108
PMCID: PMC3223475

Genes

EGFR
PTPRS
PTEN
RICTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22065749-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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