Article
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
Annals of the rheumatic diseases - 1 Jul 2013
Williams Frances M K, Bansal Aruna T, van Meurs Joyce B, Bell Jordana T, Meulenbelt Ingrid, Suri Pradeep, Rivadeneira Fernando, Sambrook Philip N, Hofman Albert, Bierma-Zeinstra Sita, Menni Cristina, Kloppenburg Margreet, Slagboom P Eline, Hunter David J, MacGregor Alex J, Uitterlinden Andre G, Spector Tim D
Abstract excerpt
OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. To date, the agnostic search of the genome by genome-wide association (GWA) to identify common variants associated with LDD has not been fruitful. This study is the first GWA meta-analysis of...
Topics
- Adult
- Aged
- CpG Islands
- DNA Methylation
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Intervertebral Disc Degeneration