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Article

The association of lumbar intervertebral disc degeneration with low back pain is modified by underlying genetic propensity to pain.

The spine journal : official journal of the North American Spine Society - 1 Jan 2025

Suri Pradeep, Naeini Maryam Kazemi, Heagerty Patrick J, Freidin Maxim B, Smith Isabelle Granville, Elgaeva Elizaveta E, Compte Roger, Tsepilov Yakov A, Williams Frances M K

Abstract excerpt

BACKGROUND CONTEXT: Associations between magnetic resonance imaging (MRI)-detected lumbar intervertebral disc degeneration (LDD) and LBP are often of modest magnitude. This association may be larger in specific patient subgroups. PURPOSE: To examine whether the association between LDD and LBP is modified by underlying genetic predispositions to pain. STUDY DESIGN: Cross-sectional study in UK Biobank (UKB) and...

Topics

Adult
Aged
Female
Humans
Male
Middle Aged
Cross-Sectional Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Intervertebral Disc Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Low Back Pain

Lumbar Vertebrae

Magnetic Resonance Imaging

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 38942297
DOI: 10.1016/j.spinee.2024.05.018
PMCID: PMC11637947

Genes

LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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