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Article

GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.

Arthritis and rheumatism - 1 Mar 2011

Williams F M K, Popham M, Hart D J, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden A G, Arden N K, Cooper C, Spector T D, Valdes A M, van Meurs J

Abstract excerpt

OBJECTIVE: Lumbar disc degeneration (LDD) is a serious social and medical problem which has been shown to be highly heritable. It has similarities with peripheral joint osteoarthritis (OA) in terms of both epidemiology and pathologic processes. A few known genetic variants have been identified using a candidate gene approach, but many more are thought to exist. GDF5 is a gene whose variants have been shown to...

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Source

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Identifiers

PMID: 21360499
DOI: 10.1002/art.30169
PMCID: PMC3498734

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.PMID 21360499Read ↗

Association between GDF5 single nucleotide polymorphism rs143383 and lumbar disc degenerationSemantic proximity Read ↗

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An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.Semantic proximity Read ↗

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