Article
Mutations in DNA-binding loop of NFAT5 transcription factor produce unique outcomes on protein-DNA binding and dynamics.
The journal of physical chemistry. B - 24 Oct 2013
Li Minghui, Shoemaker Benjamin A, Thangudu Ratna R, Ferraris Joan D, Burg Maurice B, Panchenko Anna R
Abstract excerpt
The nuclear factor of activated T cells 5 (NFAT5 or TonEBP) is a Rel family transcriptional activator and is activated by hypertonic conditions. Several studies point to a possible connection between nuclear translocation and DNA binding; however, the mechanism of NFAT5 nuclear translocation and the effect of DNA binding on retaining NFAT5 in the nucleus are largely unknown. Recent experiments showed that...
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