Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation.

Thrombosis and haemostasis - 1 Nov 2021

Cai Xiaofeng, Panicker Sumith R, Biswas Indranil, Giri Hemant, Rezaie Alireza R

Abstract excerpt

Activated protein C (APC) is an anticoagulant plasma serine protease which exhibits potent cytoprotective and anti-inflammatory activities. Here, we studied protective effects of APC on the proinflammatory function of polyinosinic:polycytidylic acid [poly(I:C)], a synthetic analog of viral double-stranded RNA, in cellular and animal models. Poly(I:C) induced histone H3 extranuclear translocation via interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Traps

Share to Neutrophils

Share to Poly I-C

Share to Protein-Arginine Deiminase Type 4

Share to Protein C

Share to Receptor, PAR-1

Source

Open in PubMed Open full text

Identifiers

PMID: 33706396
DOI: 10.1055/s-0041-1726093
PMCID: PMC8433266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation.PMID 33706396Read ↗

Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokinesSemantic proximity Read ↗

Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic SclerosisSemantic proximity Read ↗

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3Semantic proximity Read ↗

Protein C anticoagulant and cytoprotective pathways.Semantic proximity Read ↗

Double-stranded RNA induces molecular and inflammatory signatures that are directly relevant to COPDSemantic proximity Read ↗

Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cellsSemantic proximity Read ↗

Implication of glomerular endothelial expression of interferon-stimulated gene 20, an antiviral effector protein, in human kidney inflammationSemantic proximity Read ↗

Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype.Semantic proximity Read ↗

CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathwaysSemantic proximity Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

Paternal high molecular weight poly I:C administration alters the sperm small non-coding RNA profile and offspring brain development and behavioural phenotype.Semantic proximity Read ↗

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.