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Article

The homeodomain region controls the phenotype of HOX-induced murine leukemia.

Blood - 8 Nov 2012

Breitinger Constanze, Maethner Emanuel, Garcia-Cuellar Maria-Paz, Slany Robert K

Abstract excerpt

HOX proteins are widely involved in hematopoietic development. These transcription factors combine a conserved DNA-binding homeobox with a divergent N-terminus that mediates interaction with variable cofactors. The resulting combinatorial diversity is thought to be responsible for mammalian HOX specificity. Contrasting this proposed mechanism for normal HOX function, here we demonstrate that, in the context of...

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Topics

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Share to Cell Transformation, Neoplastic
Share to Cluster Analysis
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Homeodomain Proteins

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Share to Mice, Inbred BALB C

Share to Protein Interaction Domains and Motifs

Source

Identifiers

PMID: 22990017
DOI: 10.1182/blood-2011-10-384685

Genes

HOXA1
HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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