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Article

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.

Experimental hematology - 1 Jun 2013

Beachy Sarah H, Onozawa Masahiro, Silverman Deborah, Chung Yang Jo, Rivera Mariela Martinez, Aplan Peter D

Abstract excerpt

Hoxa9 is expressed in hematopoietic stem and progenitor cells, although this expression is usually diminished as these cells undergo differentiation. In addition, aberrant expression of Hoxa9 is strongly associated with both T cell and myeloid leukemia in mice and humans. Despite this strong association, enforced expression of Hoxa9 in murine bone marrow or thymus has only shown a modest ability to transform...

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Identifiers

PMID: 23435313
DOI: 10.1016/j.exphem.2013.02.006
PMCID: PMC3718276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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