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Article

Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men.

Journal of hepatology - 1 Jan 2013

Borkham-Kamphorst Erawan, Zimmermann Henning W, Gassler Nikolaus, Bissels Ute, Bosio Andreas, Tacke Frank, Weiskirchen Ralf, Kanse Sandip M

Abstract excerpt

BACKGROUND & AIMS: Factor VII activating protease (FSAP) is a circulating serine protease produced in the liver. A single nucleotide polymorphism (G534E, Marburg I, MI-SNP) in the gene encoding FSAP (HABP2) leads to lower enzymatic activity and is associated with enhanced liver fibrosis in humans. FSAP is activated by damaged cells and its substrates include growth factors and hemostasis proteins. METHODS: We...

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Source

Identifiers

PMID: 22989567
DOI: 10.1016/j.jhep.2012.09.007

Genes

HABP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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